Figure 6. In vitro drug testing.

Cultured 3635PXA cells were exposed to small molecule inhibitors (0.01 to 10 μM) for 7 days and plotted as the fraction of cell killing. (A) Two of the 7 Inhibitors targeting BRAF V600E (left panel) and 2 of the 9 inhibitors against BRAF wild-type and RAF (right panel) were active. Proliferation of the 3635PXA cells were not affected by the remaining agents. (B) Chemotherapy agent Vincristine was included as reference.