Table 1. Clinicopathologic characteristics in relation to L1 cell adhesion molecule (L1CAM) expression.
| Total | L1CAM <10% | L1CAM ≥10% | ||
|---|---|---|---|---|
| N a (%) | N (%) | N (%) | P-value | |
| Age, yrs | ||||
| 20-35 | 92 (25) | 67 (73) | 25 (27) | |
| 36-45 | 118 (32) | 93 (79) | 25 (21) | |
| 46-55 | 79 (21) | 63 (80) | 16 (20) | |
| 56-100 | 83 (22) | 69 (83) | 14 (17) | 0.409 |
| HPV type | ||||
| Negative | 32 (9) | 21 (66) | 11 (34) | |
| 16 | 177 (48) | 157 (89) | 20 (11) | |
| 18 | 58 (16) | 36 (62) | 22 (38) | |
| Other | 45 (12) | 32 (71) | 13 (29) | <0.001 |
| Unknown | 60 (16) | |||
| FIGO | ||||
| IA | 4 (1) | 3 (75) | 1 (25) | |
| IB | 307 (83) | 241 (79) | 66 (21) | |
| IIA | 52 (14) | 41 (79) | 11 (21) | |
| IIB | 8 (2) | 7 (88) | 1 (12) | |
| IIIA | 1 (<1) | 0 (0) | 1 (100) | 0.397 |
| Histopathology | ||||
| SCC | 266 (72) | 225 (85) | 41 (15) | |
| AS | 12 (3) | 8 (67) | 4 (33) | |
| A | 94 (25) | 59 (63) | 35 (37) | <0.001 |
| Tumor size | ||||
| < 40 mm | 228 (61) | 182 (80) | 46 (20) | |
| ≥ 40 mm | 121 (33) | 92 (76) | 29 (24) | 0.412 |
| Unknown | 23 (6) | |||
| Infiltration depth | ||||
| < 15 mm | 224 (60) | 173 (77) | 51 (23) | |
| ≥ 15 mm | 136 (37) | 110 (81) | 26 (19) | 0.413 |
| Unknown | 12 (3) | |||
| Parametrial invasion | ||||
| Negative | 316 (85) | 247 (78) | 69 (22) | |
| Positive | 42 (11) | 34 (81) | 8 (19) | 0.680 |
| Unknown | 14 (4) | |||
| Vasoinvasion | ||||
| Negative | 153 (41) | 116 (76) | 37 (24) | |
| Positive | 197 (53) | 159 (81) | 38 (19) | 0.268 |
| Unknown | 22 (6) | |||
| Lymph node metastasis | ||||
| Negative | 261 (70) | 206 (79) | 55 (21) | |
| Positive | 109 (29) | 85 (78) | 24 (22) | 0.840 |
| Unknown | 2 (1) |
a Total number of cases = 372. P-value obtained with the Chi-square test.
HPV: human papillomavirus, FIGO: International Federation of Gynaecology and Obstetrics stage for cervical carcinoma, SCC: squamous cell carcinoma, AS: adenosquamous carcinoma, A: adenocarcinoma.