Table 1. Correlation between high MCL1 gain and clinico-pathological features in full cohort of ESCC.

	Number	High MCL1 gain
		Yes	P value
Sex			0.894
Female	43	13
Male	219	64
Age			0.404
<60	109	29
≥60	153	48
Grade			0.415
I+II	153	42
III	109	35
Invasive depth			0.518
I	13	2
II	68	20
III	181	55
Vessel involvement			0.260
No	215	60
Yes	47	17
Nerve involvement			0.457
No	192	54
Yes	70	23
Lymph node metastasis			0.930
No	135	40
Yes	127	37
Site			0.314
up	13	3
middle	125	33
down	115	40
Smoking			0.500
No	155	48
Yes	107	29
Clinical stage			0.610
I-II	156	44
III-IVa	106	33
Disease progression			0.729
No	108	33
Yes	154	44
Death of esophageal cancer			0.445
No	113	36
Yes	149	41

Invasive Depth, I confined to submucosal layer; II invasion of muscular layer, III beyond the muscularis.