Figure 7. HDAC4/ERK1/2/Claudin-2 axis is highly upregulated in colon cancer.
(A). Represantative colonoscopic images of APCmin mice with wild type littermate confirming colon tumor growth in APCmin mice.; (B) immunoblot analysis of HDAC-4, claudin-2, cyclin-D1, P-ERK1/2 and P-27Kip1 using lysates prepared from wild type mice and APCmin mice of the same age and sex.