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. 2017 Sep 23;8(50):87737–87749. doi: 10.18632/oncotarget.21209

Figure 3. miR-526b restoration restrains tumor growth and lung metastasis of HCC in mice.

Figure 3

(A) SMMC-7721 cells that were transfected with miR-526b mimic or negative control (NC) mimic were subcutaneously injected into the flank of nude mice. Tumor growth curves indicated that miR-526b overexpression prohibited the growth of SMMC-7721 cells in vivo. n = 6, *P<0.05 by t test. Scale bar: 1 cm. (B) miR-526b overexpressing SMMC-7721 cells were intravenously injected into nude mice via tail vein. Lungs of mice were sectioned and stained by H&E. miR-526b overexpression significantly reduced the number of metastatic nodules in mice lungs. n = 6, *P<0.05 by t test.