Table 2. Clinical and echocardiographic characteristics in wild type and db/db mice.
| Wild-type (n) | db/db (n) | |||||
|---|---|---|---|---|---|---|
| Parameters | W8 (8) | W12 (7) | W16 (7) | W8 (7) | W12 (7) | W16 (7) |
| UCG | ||||||
| IVS, mm | 0.68 ± 0.15 | 0.64 ± 0.08 | 0.60 ± 0.10 | 0.75 ± 0.93 | 0.68 ± 0.05 | 0.68 ± 0. 06 |
| PW, mm | 0.72 ± 0.73 | 0.70 ± 0.11 | 0.63 ± 0.11 | 0.62 ± 0.11 | 0.69 ± 0.07 | 0.70 ± 0.08 |
| EDD, mm | 3.94 ± 0.42 | 4.11 ± 0.48 | 3.88 ± 0.48 | 3.57 ± 0.52 | 3.82 ± 0.30 | 3.84 ± 0.25 |
| ESD, mm | 2.47 ± 0.58 | 2.82 ± 0.47 | 2.60 ± 0.44 | 2.51 ± 0.37 | 2.62 ± 0.27 | 2.46 ± 0.44 |
| EF, % | 74.13 ± 8.26 | 66.51 ± 7.85 | 68.18 ± 6.41 | 65.66 ± 6.34 | 67.08 ± 0.18 | 71.25 ± 9.28 |
| FS, % | 38.20 ± 8.10 | 32.25 ± 5.38 | 33.00 ± 4.70 | 31.00 ± 4.41 | 31.96 ± 3.76 | 36.18 ± 8.83 |
| Weight, g | 23.65 ± 2.50 | 26.45 ± 2.87 | 28.08 ± 2.82 | 39.06 ±2.74* | 45.28 ±3.02*‡ | 50.98 ±2.49*‡ |
| Isolated heart (n= 5 for wild-type; n= 7 for db/db) | ||||||
| LVW, g | 0.12 ± 0.03 | 0.13 ± 0.03 | ||||
| HW, g | 0.15 ± 0.03 | 0.16 ±0.03 | ||||
| HW/BW (%) | 0.60 ± 0.01† | 0.31 ± 0.06 | ||||
LVW, left ventricular weight. HW, heart weight. BW, body weight. UCG, ultrasound cardiogram. IVS, interventricular septum.
PW, posterior wall, EDD, end diastolic dimension. ESD, end systolic dimension. EF, ejection fraction. FS, fractional shortening.
*Significantly higher than wild-type group.
†Significantly higher than db/db group.
‡Significantly higher than baseline W8 values.
P<0.05 was considered significant.