Table 5. Different inheritance models analysis of the SNPs in miRNA genes in the comparison between CIN and cervical cancer groups.
| SNPs | Models | Genotypes | Cervical cancer (n, %) | CIN (n, %) | After adjusted by Age | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | AIC | BIC | |||||
| rs11134527 | ||||||||
| Codominant | A/A | 223 (36.6%) | 147 (36.8%) | 1 | 0.290 | 1365.1 | 1615.8 | |
| A/G | 294 (48.3%) | 180 (45.0%) | 0.89 (0.66-1.19) | |||||
| G/G | 92 (15.1%) | 73 (18.2%) | 1.20 (0.81-1.78) | |||||
| Dominant | A/A | 223 (36.6%) | 147 (36.8%) | 1 | 0.770 | 1365.5 | 1611.3 | |
| A/G-G/G | 386 (63.4%) | 253 (63.2%) | 0.96 (0.73-1.27) | |||||
| Recessive | A/A-A/G | 517 (84.9%) | 327 (81.8%) | 1 | 0.170 | 1363.7 | 1609.5 | |
| G/G | 92 (15.1%) | 73 (18.2%) | 1.28 (0.90-1.84) | |||||
| Overdominant | A/A-G/G | 315 (51.7%) | 220 (55.0%) | 1 | 0.200 | 1363.9 | 1609.7 | |
| A/G | 294 (48.3%) | 180 (45.0%) | 0.84 (0.64-1.10) | |||||
| Log-additive | --- | --- | --- | 1.05 (0.87-1.27) | 0.600 | 1365.3 | 1611.1 | |
| rs74693964 | ||||||||
| Codominant | C/C | 576 (94.6%) | 376 (94.0%) | 1 | 0.510 | 1366.2 | 1617 | |
| C/T | 33 (5.4%) | 23 (5.8%) | 0.96 (0.54-1.73) | |||||
| T/T | 0 (0.0%) | 1 (0.2%) | NA (0.00-NA) | |||||
| Dominant | C/C | 576 (94.6%) | 376 (94.0%) | 1 | 1 | 1365.5 | 1611.4 | |
| C/T-T/T | 33 (5.4%) | 24 (6.0%) | 1.00 (0.56-1.78) | |||||
| Recessive | C/C-C/T | 609 (100.0%) | 399 (99.8%) | 1 | 0.250 | 1364.2 | 1610.1 | |
| T/T | 0 (0.0%) | 1 (0.2%) | NA (0.00-NA) | |||||
| Overdominant | C/C-T/T | 576 (94.6%) | 377 (94.2%) | 1 | 0.890 | 1365.5 | 1611.4 | |
| C/T | 33 (5.4%) | 23 (5.8%) | 0.96 (0.54-1.72) | |||||
| Log-additive | --- | --- | --- | 1.04 (0.60-1.82) | 0.890 | 1365.5 | 1611.4 | |
| rs6062251 | ||||||||
| Codominant | T/T | 272 (44.7%) | 159 (39.8%) | 1 | 0.017 | 1359.4 | 1610.2 | |
| C/T | 259 (42.5%) | 207 (51.8%) | 1.39 (1.05-1.85) | |||||
| C/C | 78 (12.8%) | 34 (8.5%) | 0.81 (0.50-1.31) | |||||
| Dominant | T/T | 272 (44.7%) | 159 (39.8%) | 1 | 0.088 | 1362.6 | 1608.5 | |
| C/T-C/C | 337 (55.3%) | 241 (60.2%) | 1.27 (0.96-1.67) | |||||
| Recessive | T/T-C/T | 531 (87.2%) | 366 (91.5%) | 1 | 0.089 | 1362.7 | 1608.5 | |
| C/C | 78 (12.8%) | 34 (8.5%) | 0.68 (0.43-1.07) | |||||
| Overdominant | T/T-C/C | 350 (57.5%) | 193 (48.2%) | 1 | 0.007 | 1358.1 | 1604.0 | |
| C/T | 259 (42.5%) | 207 (51.8%) | 1.45 (1.11-1.90) | |||||
| Log-additive | --- | --- | --- | 1.05 (0.86-1.29) | 0.620 | 1365.3 | 1611.1 | |
| rs531564 | ||||||||
| Codominant | G/G | 448 (73.6%) | 316 (79.0%) | 1 | 0.072 | 1362.3 | 1613.0 | |
| C/G | 144 (23.6%) | 80 (20.0%) | 0.85 (0.61-1.18) | |||||
| C/C | 17 (2.8%) | 4 (1.0%) | 0.32 (0.11-1.00) | |||||
| Dominant | G/G | 448 (73.6%) | 316 (79.0%) | 1 | 0.140 | 1363.3 | 1609.2 | |
| C/G-C/C | 161 (26.4%) | 84 (21.0%) | 0.79 (0.58-1.08) | |||||
| Recessive | G/G-C/G | 592 (97.2%) | 396 (99.0%) | 1 | 0.038 | 1361.2 | 1607.1 | |
| C/C | 17 (2.8%) | 4 (1.0%) | 0.34 (0.11-1.03) | |||||
| Overdominant | G/G-C/C | 465 (76.3%) | 320 (80.0%) | 1 | 0.400 | 1364.8 | 1610.7 | |
| C/G | 144 (23.6%) | 80 (20.0%) | 0.87 (0.63-1.20) | |||||
| Log-additive | --- | --- | --- | 0.76 (0.58-1.01) | 0.057 | 1361.9 | 1607.8 | |
| rs1834306 | ||||||||
| Codominant | G/G | 171 (28.1%) | 119 (29.8%) | 1 | 0.84 | 1367.2 | 1617.9 | |
| A/G | 299 (49.1%) | 190 (47.5%) | 0.92 (0.67-1.26) | |||||
| A/A | 139 (22.8%) | 91 (22.8%) | 0.90 (0.62-1.32) | |||||
| Dominant | G/G | 171 (28.1%) | 119 (29.8%) | 1 | 0.56 | 1365.2 | 1611 | |
| A/G-A/A | 438 (71.9%) | 281 (70.2%) | 0.92 (0.68-1.23) | |||||
| Recessive | G/G-A/G | 470 (77.2%) | 309 (77.2%) | 1 | 0.75 | 1365.4 | 1611.3 | |
| A/A | 139 (22.8%) | 91 (22.8%) | 0.95 (0.69-1.31) | |||||
| Overdominant | G/G-A/A | 310 (50.9%) | 210 (52.5%) | 1 | 0.79 | 1365.5 | 1611.3 | |
| A/G | 299 (49.1%) | 190 (47.5%) | 0.96 (0.74-1.26) | |||||
| Log-additive | --- | --- | --- | 0.95 (0.78-1.14) | 0.58 | 1365.2 | 1611.1 | |