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. 2017 Sep 27;8(50):88008–88020. doi: 10.18632/oncotarget.21330

Figure 5. The effects of emodin and rhein on HIF-1α-related proteins in MiaPaCa2 cells in vivo.

Figure 5

See the legend of Figure 4 for study design. HIF-1α and related proteins were determined in tumor grafts by Western blot, using β-actin as loading control. In these panels, the upper blots are representative results, and the lower histograms show target-control ratios in all tumors. The proteins examined included HIF-1α (A), HK-II (B), PFK-1 (B), VEGF (C), Akt (D), p-Akt (D), ERK1/2 (E), and p-ERK1/2 (E). *P<0.05, compared to the tumors whose carriers were treated with vehicle.