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. 2017 Sep 30;8(50):88043–88058. doi: 10.18632/oncotarget.21408

Figure 6. Effects of AKT signal pathway on IL-8-induced VSMC proliferation and migration with siRNA-TMEM98 treatment.

Figure 6

The activation status of p-AKT (S473) was detected after treatment with IL-8 and BEZ235 (PI3K inhibitor) by western blot (A). The effects of SC79 and BEZ235 on the p-GSK-3β and Cyclin D1 in AoSMC cells by western blot (B). The graphic showed the statistical data of Figure 6B (C). Western blot was used to examine the activation status of p-AKT (S473) dealt with SC79 (AKT agonist) and (or) siRNA-TMEM98 in IL-8-treated A7r5 (D). MTT and Boyden Chamber assay were assessed the proliferation and migration of IL-8-treated A7r5 cells dealt with SC79 and (or) siRNA-TMEM98 (E-G). All results were mean ± SD (n=3). *p<0.05, **p<0.01, ***p<0.001 vs control.