. 2017 Sep 22;8(50):88179–88188. doi: 10.18632/oncotarget.21165

Table 1. Pooled analyses of the association between NLRP1 polymorphisms and susceptibility to vitiligo.

SNP	Models	M	I²	P_{heterogeneity}	Stratification	case/control (N)	OR [95% CI]	P_association
rs12150220	T vs. A	Fixed	33.5%	0.222	overall/ Asian	563/1,351 (3)	1.17 [1.00~1.38]	0.057
	TT vs. AA	Fixed	0.0%	0.470	overall/ Asian	563/1,351 (3)	1.55 [0.77~1.72]	0.492
	AT vs. AA	Fixed	0.0%	0.896	overall/ Asian	563/1,351 (3)	1.32 [1.07~1.64]	0.011
	AT+TT vs. AA	Fixed	0.0%	0.861	overall/ Asian	563/1,351 (3)	1.29 [1.05~1.59]	0.014
	TT vs. AA+AT	Fixed	40.3%	0.187	overall/ Asian	563/1,351 (3)	0.97 [0.66~1.42]	0.866
	carrier T vs. A	Fixed	0.0%	0.513	overall/ Asian	563/1,351 (3)	1.15 [0.95~1.38]	0.149
rs2670660	G vs. A	Random	84.6%	< 0.001	overall	719/1,534 (5)	1.26 [0.84~1.90]	0.258
			88.2%	< 0.001	Asian	653/1,441(4)	1.19 [0.72~1.96]	0.491
			88.2%	< 0.001	P_HWE > 0.05	693/1,473 (4)	1.20 [0.75~1.90]	0.452
	GG vs. AA	Random	81.7%	< 0.001	overall	719/1,534 (5)	1.62 [0.73~3.59]	0.234
			85.9%	< 0.001	Asian	653/1,441(4)	1.40 [0.53~3.73]	0.500
			86.2%	< 0.001	P_HWE > 0.05	693/1,473 (4)	1.47 [0.58~3.71]	0.414
	AG vs. AA	Random	76.3%	0.002	overall	719/1,534 (5)	1.49 [0.88~2.53]	0.142
			78.6%	0.003	Asian	653/1,441 (4)	1.30 [0.73~2.32]	0.368
			80.7%	0.001	P_HWE > 0.05	693/1,473 (4)	1.37 [0.77~2.43]	0.289
	AG+GG vs. AA	Random	84.2%	< 0.001	overall	719/1,534 (5)	1.53 [0.84~2.81]	0.165
			86.9%	< 0.001	Asian	653/1,441 (4)	1.35 [0.68~2.66]	0.395
			87.6%	< 0.001	P_HWE > 0.05	693/1,473 (4)	1.40 [0.72~2.74]	0.327
	GG vs. AA+AG	Random	64.4%	0.024	overall	719/1,534 (5)	1.25 [0.77~2.01]	0.370
			72.9%	0.011	Asian	653/1,441(4)	1.20 [0.64~2.24]	0.573
			73.2%	0.011	P_HWE > 0.05	693/1,473 (4)	1.21 [0.68~2.13]	0.513
	carrier G vs. A	Random	56.5%	0.056	overall	719/1,534 (5)	1.18 [0.89~1.56]	0.262
			66.9%	0.028	Asian	653/1,441(4)	1.13 [0.80~1.61]	0.481
			66.8%	0.029	P_HWE > 0.05	693/1,473 (4)	1.14 [0.83~1.58]	0.420
rs6502867	C vs. T	Random	80.5%	< 0.001	overall	719/1,534 (5)	1.06 [0.70~1.61]	0.768
			64.7%	0.037	Asian	653/1,441(4)	1.29 [0.93~1.80]	0.130
			85.1%	< 0.001	P_HWE > 0.05	693/1,473 (4)	1.05 [0.65~1.70]	0.831
	CC vs. TT	Random	65.3%	0.021	overall	719/1,534 (5)	1.30 [0.62~2.72]	0.490
			52.1%	0.099	Asian	653/1,441(4)	1.73 [0.92~3.26]	0.397
			71.0%	0.016	P_HWE > 0.05	693/1,473 (4)	1.40 [0.64~3.07]	0.397
	TC vs. TT	Random	73.6%	0.004	overall	719/1,534 (5)	1.04 [0.64~1.69]	0.873
			55.7%	0.080	Asian	653/1,441(4)	1.27 [0.85~1.90]	0.238
			79.9%	0.002	P_HWE > 0.05	693/1,473 (4)	0.96 [0.55~1.69]	0.901
	TC+CC vs. TT	Random	80.1%	< 0.001	overall	719/1,534 (5)	1.07 [0.63~1.81]	0.805
			65.7%	0.033	Asian	653/1,441(4)	1.34 [0.87~2.07]	0.186
			85.1%	< 0.001	P_HWE > 0.05	693/1,473 (4)	1.01 [0.55~1.87]	0.963
	CC vs. TT+TC	Fixed	37.7%	0.170	overall	719/1,534 (5)	1.59 [1.21~2.09]	0.001
			15.1%	0.316	Asian	653/1,441(4)	1.69 [1.27~2.24]	< 0.001
			41.1%	0.165	P_HWE > 0.05	693/1,473 (4)	1.63 [1.24~2.16]	0.001
	carrier C vs. T	Random	54.7%	0.065	overall	719/1,534 (5)	1.07 [0.79~1.46]	0.653
			10.8%	0.339	Asian	653/1,441(4)	1.26 [1.04~1.53]	0.021
			65.9%	0.032	P_HWE > 0.05	693/1,473 (4)	1.05 [0.79~1.46]	0.782

SNP, Single Nucleotide Polymorphism; HWE, Hardy-Weinberg equilibrium; P_{heterogeneity}, P value of Cochrane's Q statistic for the assessment of heterogeneity; M, statistical model; OR, odds ratio; CI, confidence interval; P_association, P value of association test;

N, Number of included case-control studies.