Table 5. Multiple logistic regression analysis for CAD patients and control subjects in Uygur Chinese.
Variants | Factors | B | S.E. | Wald | P | OR | 95% CI |
---|---|---|---|---|---|---|---|
SREBP-1 rs9902941 | Recessive model | 0.589 | 0.283 | 4.347 | 0.037 | 1.803 | 1.036–3.137 |
Age | 0.016 | 0.011 | 2.224 | 0.136 | 1.016 | 0.995–1.039 | |
Gender | −0.129 | 0.192 | 0.449 | 0.503 | 0.879 | 0.603–1.281 | |
Smoking | 0.228 | 0.200 | 1.294 | 0.255 | 1.256 | 0.848–1.859 | |
Drinking | 0.475 | 0.204 | 5.423 | 0.020 | 1.608 | 1.078–2.400 | |
Hypertension | 0.495 | 0.152 | 10.661 | 0.001 | 1.640 | 1.219–2.207 | |
FPG | 0.077 | 0.029 | 7.249 | 0.007 | 1.080 | 1.021–1.143 | |
TG | 0.062 | 0.060 | 1.046 | 0.307 | 1.064 | 0.945–1.198 | |
TC | −0.054 | 0.088 | 0.378 | 0.539 | 0.947 | 0.797–1.126 | |
HDL-C | −0.913 | 0.263 | 12.085 | 0.001 | 0.401 | 0.240–0.671 | |
LDL-C | 1.017 | 0.166 | 37.687 | < 0.001 | 2.765 | 1.998–3.825 | |
SREBP-2 rs7288536 | Additive model | 0.313 | 0.151 | 4.331 | 0.037 | 1.368 | 1.018–1.837 |
Age | 0.017 | 0.011 | 2.527 | 0.112 | 1.018 | 0.996–1.040 | |
Gender | −0.116 | 0.192 | 0.365 | 0.546 | 0.890 | 0.611–1.298 | |
Smoking | 0.248 | 0.200 | 1.545 | 0.214 | 1.282 | 0.866–1.897 | |
Drinking | 0.517 | 0.204 | 6.418 | 0.011 | 1.677 | 1.124–2.503 | |
Hypertension | 0.487 | 0.151 | 10.343 | 0.001 | 1.628 | 1.210–2.190 | |
FPG | 0.078 | 0.029 | 7.410 | 0.006 | 1.081 | 1.022–1.144 | |
TG | 0.059 | 0.061 | 0.934 | 0.334 | 1.061 | 0.941–1.195 | |
TC | −0.050 | 0.089 | 0.316 | 0.574 | 0.951 | 0.799–1.133 | |
HDL-C | −0.883 | 0.268 | 10.877 | 0.001 | 0.414 | 0.245–0.699 | |
LDL-C | 1.018 | 0.166 | 37.785 | < 0.001 | 2.767 | 2.000–3.828 | |
FBXW7 rs10033601 | Recessive model | 0.487 | 0.209 | 5.413 | 0.020 | 1.628 | 1.080–2.454 |
Age | 0.017 | 0.011 | 2.539 | 0.111 | 1.018 | 0.996–1.040 | |
Gender | −0.151 | 0.193 | 0.612 | 0.434 | 0.860 | 0.590–1.255 | |
Smoking | 0.251 | 0.200 | 1.575 | 0.210 | 1.285 | 0.868–1.902 | |
Drinking | 0.512 | 0.204 | 6.305 | 0.012 | 1.669 | 1.119–2.490 | |
Hypertension | 0.476 | 0.152 | 9.861 | 0.002 | 1.610 | 1.196–2.166 | |
FPG | 0.082 | 0.029 | 8.143 | 0.004 | 1.086 | 1.026–1.149 | |
TG | 0.061 | 0.061 | 0.994 | 0.319 | 1.062 | 0.943–1.197 | |
TC | −0.065 | 0.089 | 0.522 | 0.470 | 0.937 | 0.787–1.117 | |
HDL-C | −0.892 | 0.266 | 11.227 | 0.001 | 0.410 | 0.243–0.691 | |
LDL-C | 1.012 | 0.166 | 37.327 | < 0.001 | 2.752 | 1.989–3.807 |
FPG, fasting plasma glucose; TG, triglyceride; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol