Table 3.
Demographic and Clinicopathological Parameters of HCC Patients with miR-135a Levels Higher or Lower in Tumor Than the Adjacent Normal Region
| Variable | Total | miR-135a T > N |
miR-135a T < N |
p Value |
|---|---|---|---|---|
| n (%) | n (%) | |||
|
Atg14 mRNA Expression (T/N) | ||||
| T > N | 13 | 6 (46.2) | 7 (53.8) | p < 0.001 |
| T < N | 90 | 84 (93.3) | 6 (6.7) | p < 0.001 |
| Age | ||||
| ≥50 years | 85 | 74 (87.1) | 11 (12.9) | p = 0.832 |
| <50 years | 18 | 16 (88.9) | 2 (11.1) | p = 0.832 |
| Sex | ||||
| Male | 82 | 72 (87.8) | 10 (12.2) | p = 0.797 |
| Female | 21 | 18 (85.7) | 3 (14.3) | p = 0.797 |
| Cirrhosis | ||||
| Present | 61 | 52 (85.2) | 9 (14.8) | p = 0.432 |
| Absent | 42 | 38 (90.5) | 4 (9.5) | p = 0.432 |
| Hepatitis | ||||
| B | 71 | 68 (95.8) | 3 (4.2) | p = 0.002 |
| C | 14 | 9 (64.3) | 5 (35.7) | p = 0.002 |
| B + C | 3 | 2 (66.7) | 1 (33.3) | p = 0.002 |
| NBNC | 15 | 11 (73.3) | 4 (26.7) | p = 0.002 |
| HBs-Ag | ||||
| Positive | 74 | 70 (94.6) | 4 (5.4) | p < 0.001 |
| Negative | 29 | 20 (69) | 9 (31) | p < 0.001 |
| Pathology Stage | ||||
| I, II | 69 | 57 (82.6) | 12 (17.4) | p = 0.038 |
| III, IV | 34 | 33 (97.1) | 1 (2.9) | p = 0.038 |
| T_stage | ||||
| 1, 2 | 68 | 56 (82.4) | 12 (17.6) | p = 0.032 |
| 3, 4 | 35 | 34 (97.1) | 1 (2.9) | p = 0.032 |
| N_stage | ||||
| n0 | 101 | 88 (87.1) | 13 (12.9) | p = 0.587 |
| n1 | 2 | 2 (100) | 0 (0) | p = 0.587 |
| M_stage | ||||
| n0 | 99 | 86 (86.9) | 13 (13.1) | p = 0.438 |
| n1 | 4 | 4 (100) | 0 (0) | p = 0.438 |
| Tumor Size | ||||
| ≥5 cm | 51 | 44 (86.3) | 7 (13.7) | p = 0.738 |
| <5 cm | 52 | 46 (88.5) | 6 (11.5) | p = 0.738 |
| Tumor Number | ||||
| 1 | 92 | 80 (87) | 12 (13) | p = 0.505 |
| 2 | 7 | 7 (100) | 0 (0) | p = 0.505 |
| 3 | 3 | 2 (66.7) | 1 (33.3) | p = 0.505 |
| 4 | 1 | 1 (100) | 0 (0) | p = 0.505 |
| Recurrent | ||||
| Present | 63 | 60 (95.2) | 3 (4.8) | p = 0.003 |
| Absent | 40 | 30 (75) | 10 (25) | p = 0.003 |
| Microvascular Invasion | ||||
| Present | 66 | 62 (93.9) | 4 (6.1) | p = 0.007 |
| Absent | 37 | 28 (75.7) | 9 (24.3) | p = 0.007 |
| AFP | ||||
| <70 ng/mL | 65 | 53 (81.5) | 12 (18.5) | p = 0.02 |
| ≥70 ng/mL | 38 | 37 (97.4) | 1 (2.6) | p = 0.02 |
| mean (95% CI) | mean (95% CI) | |||
| AST(U/L) | 103 | 51.1 (40.9–61.2) | 48.3 (28.6–68) | p = 0.845 |
| ALT(U/L) | 103 | 52.2 (42.3–61.9) | 59.4 (23–95.9) | p = 0.612 |
T/N, tumor versus non-tumor adjacent tissue expression levels; HBs-Ag, hepatitis B virus surface antigen.