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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Neurobiol Dis. 2017 Aug 30;108:183–194. doi: 10.1016/j.nbd.2017.08.018

Figure 2. TLE subiculum neurons exhibit pro-excitatory alterations in sodium channel physiology.

Figure 2

(A) Representative current traces recorded using the outside-out patch clamp configuration for WT and TLE subiculum neurons. (B) Voltage dependence of channel activation for WT (black, n=19) and TLE (red, n=14) subiculum neurons. Lines correspond to the least-squares fit when average data were fit to a single Boltzmann equation. (C) Scatter plot of voltage at half-maximal activation (V1/2) for WT and TLE subiculum neurons. (D) Scatter plot of the slope factor (k) of activation in WT and TLE subiculum neurons. (E) Voltage dependence of channel inactivation for WT (black, n=12) and TLE (red, n=18) subiculum neurons. Lines correspond to the least-squares fit when average data were fit to a single Boltzmann equation. (F) Scatter plot of voltage at half-maximal inactivation (V1/2) for WT and TLE subiculum neurons. (G) Scatter plot of the slope factor (k) of inactivation. (H) Window current predicted by overlapping normalized activation and inactivation curves. Estimated window current is elevated in TLE subiculum neurons (red checkered area) compared to WT (black checkered area). Data represent mean ± S.E.M. Statistical significance: *P<0.05 Student’s T-Test with Welch’s correction.