. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Neurobiol Dis. 2017 Aug 30;108:183–194. doi: 10.1016/j.nbd.2017.08.018

Table 1.

Membrane Properties of WT and TLE Subiculum Neurons

	RMP, mV	R_i, MΩ	Threshold, mV	Amplitude, mV	AP Width (ms)	Upstroke Velocity, mV/ms	Rheobase (pA)	N
WT	−61.3 ± 0.2	66.0 ± 2.9	−45.7 ± 0.3	96.6 ± 0.8	0.87 ± 0.0	359.0 ± 18.5	94.4 ± 5.0	16
TLE	−61.5 ± 0.2	86.8 ± 5.1^**	−50.4 ± 0.6^**	98.9 ± 1.4	0.95 ± 0.0^**	315.8 ± 27.2	50.8 ± 5.3^**	12
WT + 4,9-ah-TTX (100 nM)	−59.3 ± 0.3 ^††	48.9 ± 2.7 ^††	−41.6 ± 0.3 ^††	90.0 ± 1.6 ^††	0.99 ± 0.0 ^††	346.2 ± 16.0	188 ± 10.8 ^††	7
TLE + 4,9-ah-TTX (100 nM)	−59.6 ± 0.2 ^††	76.8 ± 9.7	−42.9 ± 0.4 ^††	95.0 ± 2.9	1.1 ± 0.3 ^††	243.1 ± 20.3^†	100 ± 7.3 ^††	6

Values represent mean ± S.E.M, n= number of cells. RMP; Resting membrane potential. R_i; input resistance.

^**

p<0.01 compared to WT,

^†

p<0.05 compared to no 4,9-ah-TTX,

^††

p<0.01 compared to no 4,9-ah-TTX, Student’s T-test with Welch’s Correction