Table 1.
Correlation between SULT1A1 CNV and Estrogen sulfation
| Gender (sample size) |
Metabolite | Categories of CNV (Mean±SD) | r (p-value) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CP0 (n=3F, 2M) |
CP1 (n=10F, 10M) |
CP2 (n=10F, 10M) |
CP3 (n=10F, 10M) |
CP4 (n=10F, 10M) |
CP5 (n=6F, 6M) |
CP6 (n=0F, 2M) |
|||
| Male (n=50) | E1 (pg/mL serum) | 25.18±15.34 | 25.34±18.57 | 48.02±45.49 | 52.03±46.30 | 48.71±28.53 | 41.68±21.88 | 27.55±6.07 | 0.23 (0.11) |
| E1S (ng/mL serum) | 2.92±0.36 | 2.82±0.77 | 2.72±1.44 | 4.03±1.38 | 2.21±0.77 | 2.51±0.77 | 1.17±0.021 | −0.22 (0.11) | |
| E1S/E1 | 147.81 ± 104.27 | 182.61±137.54 | 80.63±45.73 | 142.38±114.90 | 83.12±80.11 | 75.84±43.85 | 43.57±8.84 | −0.32 (0.025) | |
| DHEA (pg/mL serum) | 24614.97±2953.30 | 21104.87±9556.66 | 37211.83±26096.38 | 30202.69±22522.43 | 31417.76±24561.34 | 32065.90±8646.91 | 40043.00±1870.94 | 0.26 (0.06) | |
| DHEAS (ng/mL serum) | 2491.77±511.21 | 3740.32±5343.70 | 13158.48±24639.23 | 8316.33±14730.70 | 2826.07±3308.61 | 3952.67±3909.26 | 2804.18±448.25 | −0.005 (0.97) | |
| DHEAS/DHEA | 100.71± 8.69 | 284.73± 613.71 | 345.25± 434.25 | 256.08± 322.08 | 119.67± 147.13 | 118.24± 104.96 | 70.37± 14.48 | −0.20 (0.16) | |
| Female (n=49) | E1 | 68.61±39.60 | 57.86±52.49 | 74.08±46.69 | 77.69±45.60 | 175.07±186.32 | 84.89±86.97 | NA | 0.19 (0.20) |
| E1S | 4.38±3.06 | 2.72±1.53 | 2.88±0.48 | 3.05±0.93 | 3.56±2.29 | 2.78±0.92 | NA | 0.03 (0.85) | |
| E1S/E1 | 70.74 ±34.23 | 300.85 ±481.30 | 55.63±39.31 | 68.99±66.23 | 40.17±45.87 | 92.57±84.91 | NA | −0.21 (0.15) | |
| DHEA | 19644.86±9322.50 | 47853.93±38728.78 | 32841.50±18937.03 | 33987.81±23845.05 | 46801.92±54419.97 | 16745.35±6075.99 | NA | −0.17(0.25) | |
| DHEAS | 927.29±243.11 | 3353.70±3109.54 | 1751.68±1036.42 | 1114.11±506.36 | 1458.83±779.25 | 1167.37±381.91 | NA | −0.17 (0.26) | |
| DHEAS/DHEA | 54.33± 30.07 | 76.54± 61.26 | 67.60± 44.77 | 39.52± 17.04 | 44.52± 25.88 | 79.81± 40.99 | NA | −0.04 (0.77) | |
| Female + Male (n=99) | E1 | 51.23±37.54 | 40.64±40.72 | 61.05±46.82 | 64.86±46.62 | 115.21±148.05 | 61.32±61.43 | 27.55±6.07 | 0.14 (0.17) |
| E1S | 3.79±2.32 | 2.77±1.18 | 2.80±1.05 | 3.54±1.25 | 2.88±1.80 | 2.65±0.82 | 1.17±0.021 | −0.10 (0.31) | |
| E1S/E1 | 101.57 ± 71.32 | 238.25±338.39 | 68.13±43.44 | 105.69±98.73 | 60.51±66.26 | 84.20±62.62 | 43.57±8.84 | −0.21 (0.035) | |
| DHEA | 21632.90±7283.24 | 34479.40±30692.70 | 35026.66±22304.34 | 32095.25±22657.93 | 39109.84±41843.38 | 24405.63±10713.59 | 40043.00±1870.94 | 0.04 (0.71) | |
| DHEAS | 1553.08±910.58 | 3547.01±4259.76 | 7154.90±17452.69 | 4715.22±10796.22 | 2142.45±2442.32 | 2560.02±3021.36 | 2804.18±448.25 | −0.08 (0.43) | |
| DHEAS/DHEA | 72.88± 33.41 | 180.64± 437.72 | 206.43± 332.50 | 142.10± 242.06 | 82.09± 109.81 | 99.03± 78.58 | 70.37± 14.48 | −0.08 (0.41) | |
Abbreviations: CP0, CP1, CP2, CP3, CP4, CP5, and CP6 stands for the number of copy number variants 1–6 for SULT1A1; r (p-value), Spearman’s rank correlation coefficient and p-value.