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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Clin J Pain. 2017 Dec;33(12):1071–1080. doi: 10.1097/AJP.0000000000000509

Figure 2. PIO Attenuated Whisker Pad Mechanical Allodynia in the Mice with TIC Injury.

Figure 2

Hypersensitivity was attenuated by specific PPARγ agonism with (A) PIO rapidly elevating the 50% mechanical threshold in the mice with TIC at higher doses (300 mg/kg and 600 mg/kg), but was ineffective at 100 mg/kg (n=3–7). (B) GW0742, PPARβ agonist, attenuated mechanical allodynia in the mice with TIC injury at a dose of 6 mg/kg, but was not as effective as PIO (n=4–6). (C) PPARα agonists, Bezafibrate and fenofibrate at indicated doses, were not effective in alleviating mechanical allodynia in the mice with TIC injury (n=3–6). (D) PPARγ antagonist, GW9662, blocked the anti-allodynic effect of PIO at a dose of 30 mg/kg (n=4–7). (*p<0.05, ****p<0.0001; two-way ANOVA, Fisher’s post hoc test)