Table 3. Mutation carriers.

Results from linear models, examining the differences in Pittsburgh Compound B positron emission tomography (PiB PET) measured brain amyloid burden and CSF biomarkers between the low and high exercise groups (models also included family mutation, EYO, age, and an EYO^*exercise interaction).

	Exercise*					Family Mutation			EYO			Age**			EYO*Exercise
Dependent variable	Low exerciseMean (SE) Ɨ	High exerciseMean (SE) Ɨ	F	p	ηp2	F	p	ηp2	F	p	ηp2	F	p	ηp2	F	p	ηp2
PiB SUVR (n = 139)	1.59 (0.12)	1.58 (0.09)	2.68	0.10	0.020	2.42	0.09	0.035	41.30	<0.001	0.238	1.86	0.17	0.014	3.32	0.07	0.025
CSF Aβ42 (ng/L) (n = 120)	337.5 (30.7)	349.1 (22.9)	0.01	0.95	0.001	1.54	0.22	0.026	21.05	<0.001	0.157	0.01	0.99	0.001	0.04	0.85	0.001
CSF tau (ng/L) (n = 121)	81.0 (9.4)	82.1 (6.9)	0.25	0.62	0.002	0.85	0.43	0.015	13.4	<0.001	0.105	0.14	0.71	0.001	0.25	0.61	0.002

^*Low exercisers reported less than 150 minutes per week of exercise, high exercisers reported 150 or more minutes of exercise per week.

^**The age variable was residualized from EYO.

^ƗAdjusted marginal means (standard error).

Abbreviations: CSF, cerebrospinal fluid; EYO, estimated years from expected symptom onset; ng/L, nanograms per litre; PiB SUVR, Pittsburgh Compound B standardised uptake value ratio; SE, standard error.