Table 4. Mutation carriers stratified by brain amyloid load.

Results from linear models, examining the differences in Pittsburgh Compound B positron emission tomography (PiB PET) measured brain amyloid burden and CSF biomarkers between the low and high exercise groups, following stratification of the mutations carriers by PiB PET SUVR status (models also included family mutation, EYO, age, and an EYO^*exercise interaction).

		Exercise*					Family Mutation			EYO			Age**			EYO*Exercise
		Low exercise Mean (SE) Ɨ	High exercise Mean (SE) Ɨ	F	p	ηp2	F	p	ηp2	F	p	ηp2	F	p	ηp2	F	p	ηp2
PiB SUVR	MC PiB − (n = 68)	1.09 (0.03)	1.11 (0.02)	1.16	0.28	0.019	0.30	0.74	0.010	2.27	0.14	0.036	0.97	0.33	0.016	0.48	0.49	0.008
	MC PiB + (n = 71)	2.36 (0.19)	2.16 (0.15)	8.20	0.006a	0.114	0.51	0.60	0.016	16.22	<0.001	0.202	1.92	0.17	0.029	7.04	0.01a	0.099
CSF Aβ42 (ng/L)	MC PiB − (n = 57)	387.0 (47.3)	427.8 (31.3)	0.15	0.70	0.003	3.02	0.06	0.108	1.27	0.26	0.025	0.47	0.50	0.009	0.00	0.99	0.001
	MC PiB + (n = 63)	269.0 (34.9)	290.3 (30.4)	0.34	0.56	0.006	0.06	0.94	0.002	7.36	0.01	0.116	0.38	0.54	0.007	0.02	0.88	0.001
CSF tau (ng/L)	MC PiB − (n = 57)	57.5 (8.6)	64.1 (5.7)	0.01	0.98	0.001	0.30	0.74	0.012	1.03	0.31	0.020	0.15	0.70	0.003	0.16	0.69	0.003
	MC PiB + (n = 64)	109.9 (16.1)	94.3 (13.4)	0.51	0.48	0.009	1.16	0.32	0.039	2.22	0.14	0.037	1.16	0.29	0.020	3.16	0.08	0.052

^*Low exercisers reported less than 150 minutes per week of exercise, high exercisers reported 150 or more minutes of exercise per week.

^**The age variable was residualized from EYO.

^ƗAdjusted marginal means (standard error).

^ap-value remained significant (p < 0.05) after false discovery rate correction.

Abbreviations: CSF, cerebrospinal fluid; EYO, estimated years from expected symptom onset; MC, mutation carriers; ng/L, nanograms per litre; PiB SUVR, Pittsburgh Compound B standardised uptake value ratio; PiB -, PiB negative with an SUVR of less than 1·3; PiB +, PiB positive with an SUVR of 1·3 or higher SE, standard error.