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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Antiviral Res. 2017 Sep 20;147:116–123. doi: 10.1016/j.antiviral.2017.09.012

Fig. 4. Mice immunized with MS2-L2 VLPs elicit protective antibody responses against HPV PsV31, 45, 58, and 16.

Fig. 4

Fig. 4

Mice vaccinated with MS2-L2 VLPs or MS2 control VLPs were vaginally challenged with ~6.4 × 106 IU of HPV PsVs. Forty-eight hours post-challenge, luciferin was instilled vaginally and images were taken 3 minutes post-luciferin instillation except in 4A were images were taken 10 minutes post-luciferin instillation. The average radiance (p/s/cm2/sr) of luciferase expression at the genitals was determined using Living Image 3.2 software. Each datum represents the radiance value of an individual mouse and the lines stand for the average geometric mean for each group. Red dashed lines highlight MS2-L2 VLPs efficacy in comparison to Gardasil-9 vaccine.