Table 5.
Whole Brain Analysis for Studies with Controls
| Study | Statistical Analysis of Whole Brain | Confounding Covariates entered | Significance Threshold | Non-Stationarity Adjustment | Correction for Variance | Implicit Masking |
|---|---|---|---|---|---|---|
| Allen et al. | Analysis of covariance (ANCOVA) regression model | Whole brain volume and white matter volume | P<0.05 FWE corrected at the cluster level (assumed) | None | NA | NA |
| Boyen et al. | First a one-way ANCOVA regression model for equality between groups than a two sample t-test between groups | Age | P<0.05 FWE corrected at the cluster level | None | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |
| Husain et al. | First an ANOVA for equality between groups than a two sample t-test between groups | Whole brain volume | P<0.001 uncorrected at voxel level and P<0.05 FWE and FDR corrected at cluster level | None | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |
| Krick et al. | Two-way ANCOVA | None | P<.05 FWE corrected at the cluster level | None | NA | NA |
| Landgrebe et al. | Two sample t-test | Whole brain volume | P<0.05 FDR corrected at voxel level | NA | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |
| Leaver et al. (2011) | Two sample t-test | Age, total gray or white matter volume | P<0.0001 uncorrected at the voxel level | NA | NA | Excluded all voxels with a GM value <0.2 |
| Leaver et al. (2012) | t-tests between groups | None | P<.002 uncorrected at the voxel level | NA | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |
| Mahoney et al. | T test between groups(assumed) | Whole brain volume, age, gender | P<.05 FWE corrected at the voxel level | NA | NA | Included all voxels with intensity >0.01 in >70% of subjects |
| Melcher et al. | Two sample t-test | None | P<0.05 FWE corrected at the voxel level and P<0.001 uncorrected at the cluster level | None | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |
| Mühlau et al. | Two sample t-tests | Whole brain volume | P<0.05 FDR correction at voxel level and P<0.05 FDR corrected at the cluster level | None | Non-sphericity correction | Excluded all voxels with a GM value <0.2 |