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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: J Immunol. 2017 Oct 9;199(10):3437–3452. doi: 10.4049/jimmunol.1700953

Figure 4. Frequent sharing of public CDR3 motifs between HIV controllers and ADVAX recipients.

Figure 4

(A) The percentage of motif occurrence in the CDR3 sequence datasets from vaccinees (ADVAX), HIV controllers (HIC), and treated patients (HAART) was determined by using the sequence manipulation suite (http://www.bioinformatics.org/sms2/). Motifs are reported in single letter a.a. code; X stands for “any a.a.”; when several a.a. are possible at a given position in the motif, they are shown in brackets.

(B) The sum of AV24-1 and AV24-2 motif frequencies (left) and of BV2-1 an BV-2 motif frequencies (right) are plotted. (C) The sum of AV24-3 and AV24-4 frequencies (left) and the BV2-3 motif frequency (right) are plotted. (B, C) Significant differences (P < 0.05) between groups obtained with Fischer’s exact test are reported. Number of sequences analyzed: ADVAX TRA: 473; HIC TRA: 584; HAART TRA: 496; ADVAX TRB: 723; HIC TRB: 716; HAART TRB: 566.