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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Neurobiol Dis. 2017 Aug 17;108:195–203. doi: 10.1016/j.nbd.2017.08.002

Fig. 9.

Fig. 9

Schematic drawing of EP generation in the cochlear lateral wall. Based on the “two-cell” model, EP is generated by Kir4.1 in the apical membrane of intermediate cells in conjunction with Kir5.1 channels, Na+/K+ ATPases, and Na+, K+, 2Cl−-cotransporters in the fibrocytes through GJ coupling [40,45]. Heterozygous couplings of gap junctions between fibrocute I and II cells in the spiral ligament (SPL), between fibrocyte I cells and base cells in the stria vascularis (St. V), and between base cells and intermediate cells are important for eventually positive EP generation. MC: marginal cell; BC: basal cell; FC: fibrocyte; IC: intermediate cell; IS: intrastrial space; GJ: gap junction.