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Ly49D-mediated cytotoxicity is severely impaired by chronic engagement of NKG2D in vivo. (A,B) Redirected lysis of P815 cells loaded with (A) anti-NK1.1 or (B) anti-Ly49D antibodies by poly(I:C)-activated splenic NK cells. Data represent means of triplicates with SDs. One representative out of four independent experiments is shown. Two-way ANOVA was performed with a Sidak posttest for comparison.
