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. 2017 Nov 3;8:1441. doi: 10.3389/fimmu.2017.01441

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Copyright © 2017 Platteel, Liepe, van Eden, Mishto and Sijts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Generation of Listeria-derived spliced epitopes LLO_{291-294/297-304}, PlcB_{189-192/164-167}, and PlcB_{189-191/163-167}. (A) Structure of LLO of Listeria monocytogenes with LLO_{291-294/297-304} highlighted. Proteasome-catalyzed peptide splicing (PCPS) generates the spliced epitope precursor LLO_{291-294/297-304}. This peptide is N-terminally truncated by ERAP1 which results in LLO_294/297-304 (24). (B) L. monocytogenes PlcB_{189-192/164-167} and PlcB_{189-191/163-167} are generated from the secreted bacterial virulence factor PlcB via reverse cis-PCPS (25).