Figure 5.

P2X7 receptor activation is not observed during OGD. (A) Representative currents from a Bergmann glial cell in wild type and P2X7R^−/− mice. Mean currents are shown at the right (n = 19 and n = 8 from wild type and P2X7R^−/− mice respectively). (B) No statistical differences are observed in the electrical charge or in the time to peak of I_OGD among WT, P2X7R^−/− mice and cells from wild-type mice treated with the P2X7R antagonist, A-740003 (10 μM). For I_OGD charge: n = 19 in WT, n = 6 in A-740003 (P = 0.4) and n = 5 in P2X7R^−/− (P = 0.91); for time to peak: n = 23 in WT, n = 6 in A-740003 (P = 0.68) and n = 7 in P2X7R^−/− (P = 0.31).