Figure 8.

Schematic illustration of events that occur during ischemia simulated by OGD. Interruption of ATP production leads to an imbalance of ionic gradients resulting in an accumulation of K⁺ in extracellular space and consequent Bergmann glia depolarization. This disruption of ion homeostasis depolarizes cerebellar neurons exacerbating glutamate release that, with several minutes of delay, induces a huge depolarization in Purkinje cells. ATP extracellular concentration is also increased during OGD and is responsible, at least in part, for Ca²⁺ rises in Bergmann glial cells.