Table 2.

Current Classification of Ehlers-Danlos Syndromes.

Descriptive	Clinical features	Genes	Inheritance
Classical	Marked joint hypermobility, skin hyperextensibility, bruising, abnormal scarring	COL5A1, COL5A2	AD
Hypermobility	Marked joint hypermobility, minor skin findings	Largely unknown, TNXB	AD
Vascular	Thin translucent skin, marked bruising, small joint hypermobility, high risk for rupture of arteries, bowel and gravid uterus	COL3A1	AD
Kyphoscoliosis	Kyphoscoliosis recalcitrant to surgery, joint hypermobility, risk for arterial rupture, ocular fragility	PLOD1	AR
Arthrochalasia	Marked joint hypermobility, bilateral congenital hip dislocation	COL1A1, COL1A2	AD
Dermatosparaxis	Soft, fragile skin with late onset skin redundancy, blue sclerae, joint hypermobility	ADAMTS2	AR

AD: autosomal dominant fashion, AR: autosomal recessive fashion