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. 2017 Jul 10;14(11):924–934. doi: 10.1038/cmi.2017.8

Figure 6.

Figure 6

BTZ attenuates the Th17 response and ESS development in IL-17 KO mice. Naive CD4+ T cells from naive BoyJ mice were transferred into immunized IL-17 KO mice. Recipient mice received vehicle or BTZ treatment three times every 3 days. (a) Saliva flow rates of vehicle- or BTZ-treated mice were measured (n=6 per group, mean±s.d., *P<0.01). (b) Representative flow cytometric profiles showing Th17 cells derived from donor cells (gated on CD45.1+CD4+). (c) Statistical analysis of both the frequencies (upper panel) and total cell numbers (lower panel) of Th17 cells derived from donor cells in IL-17 KO mice (n=6 per group, mean±s.d., *P<0.05). (d, e) The vehicle or BTZ-treated recipient mice were killed at 15 weeks after the first immunization for analysis. (d) Representative images of H&E staining of the SG tissue sections showing glandular infiltration (scale bar=20 μm). (e) Representative flow cytometric analysis of infiltrating immune cells in the SG. BTZ, bortezomib; ESS, experimental Sjögren’s syndrome; KO, knockout.