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. 2017 Oct 10;16(6):1414–1424. doi: 10.1111/acel.12686

Figure 2.

Figure 2

Mixed‐class J‐protein cooperation affects polyQ‐containing protein aggregation in Caenorhabditis elegans in a tissue‐independent manner. (A) Polyglutamine Q35‐YFP aggregate quantification at day 5 in muscle tissue, with single and double knockdown of different J‐proteins (see Fig. S2C (Supporting information) for representative fluorescent images). Single and double knockdowns of J‐proteins are depicted in green (class A), blue (class B), and magenta (class A+B). N = 30 animals. P < 0.0001 one‐tailed ANOVA. (B) Quantification of Q44‐YFP aggregates in 6‐day‐old nematode intestinal tissue with single or double knockdown of dnj genes (see Fig. S2D (Supporting information) for representative fluorescent images). N = 20 animals; P < 0.0001 one‐tailed ANOVA. Error bars reflect mean ± SD.