Figure 2.

Functional analysis of the muscle proteome. (A) Functional distribution of differentially expressed proteins (DEPs) contributing to the canonical pathways (B) revealed substantial overlap and pinpointed the major differences in the expression to affect mitochondria (e.g., oxidative phosphorylation), cytoplasmic energy metabolism and various cellular signaling modules. (B) Canonical pathways analysis. Ten pathways with most significant Benjamini–Hochberg corrected P‐values are presented. PRE = premenopausal group, non‐HRT = postmenopausal women not using HRT, HRT = hormone replacement therapy, E₂‐HRT = postmenopausal women using 17β‐estradiol‐based HRT, Tib‐HRT =  postmenopausal women using tibolone‐based, B‐H = Benjamini–Hochberg correction.