Figure 2.
Adult‐specific, neuronal let‐7 overexpression increases female lifespan and TAG. (A) Ubiquitous let‐7 overexpression in females significantly decreased female lifespan (N = 225 flies for both food treatments). (B) Neuronal let‐7 overexpression significantly increased female lifespan (N = 167 flies for RU− food and 61 for RU+ food), while having the opposite effect in males (C; N = 101 flies for RU− food and 123 flies for RU+ food). (D) Neuronal let‐7 overexpression significantly increased female TAG levels (N = 50 flies per genotype/food treatment). (E) Neuronal let‐7 overexpression had no significant effect on male TAG levels (N = 50 flies per genotype/food treatment). (F) 4E‐BP mRNA levels are unaltered in females with neuronal let‐7 overexpression (N = 50 flies per genotype/food treatment).