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Schematic illustration of TCR signaling in AA. Upregulation of CD3γ, CD3, CD3ε, CD3ζ, and CD28 was detected at the mRNA level, and ZAP-70 and LAT were detected at the protein level in AA. Downregulation of CTLA-4 and Cbl-b were detected at the mRNA level, and DGKζ was examined at the mRNA and protein level in AA.
