Fig. 1. A GM biosynthetic gene cluster and an NRPS assembly line. (A) The GM biosynthetic gene cluster. The NRPS modules are shown in blue, and the genes associated with (2S,4R)-4-MePro biosynthesis are shown in red. (Annotation: Table S1†) (B) The GM assembly line. The NRPS modules are numbered 1–10, and the substrates are given in parentheses. For each module, the domains are: C = condensation, A = adenylation, MT = methyl transferase, CP = carrier protein, E = epimerase, and TE = thioesterase. (2S,4R)-4-MePro is shown in orange.
