Strict uniparental inheritance of small freely-segregating mitochondrial populations mitigates the mutational meltdown in the absence of mitochondrial recombination. Here, dm/dt denotes the rate of mutation accumulation. Mutation rate is µ = 0.005 (solid lines) or µ = 0.01 (dashed lines), population size N = 500, and C = 1. Here, s = 0.02 and K = 100. Error bars indicate the 95% C.I.s for the SEM ( where mfix is the number of fixed mutations after t generations).