Figure 3.

Example of simulated and inferred mixture of gamma and exponential DFEs. (A) Three of the simulated DFEs (Table 1) with different α values (proportion of beneficial substitutions). The DFEs are parameterized by $S_d$ (mean selection coefficient of deleterious mutations), b (shape of distribution of deleterious DFE), $p_b$ (proportion of beneficial mutations), and $S_b$ (mean selection coefficient of beneficial mutations). The inset shows a zoom-in of the beneficial part of the DFE. (B) Simulated discretized DFE (corresponding to MAMSD from Table 1), together with the mean (over the 100 replicates) inferred discretized DFE using both polymorphism and divergence data and only polymorphism data, where a full DFE and a deleterious DFE was inferred.