Table 3. Results of bipolar disorder GWAS data application: genes with genome-wide significance (P-value < 2.4 × 10⁻⁶) by COMBAT and corresponding results by SNP-level analysis (minimum P-value) and individual gene-based tests.

Genes	SNP (minP)	GATES	VEGAS (max)	VEGAS (10%)	VEGAS (20%)	VEGAS (sum)	SimpleM	COMBAT	Pcorrected
RHEBL1	9.43E−09	2.59E−07	4.00E−07	4.00E−07	6.00E−07	2.00E−07	3.83E−07	2.98E−07	6.12E−03
DHH	9.39E−09	3.27E−07	6.00E−07	9.00E−07	9.00E−07	5.00E−07	3.83E−07	4.19E−07	8.58E−03
LMBR1L	9.39E−09	3.88E−07	1.00E−06	1.30E−06	1.20E−06	1.90E−06	4.78E−07	5.31E−07	1.09E−02
SYNE1	4.33E−09	7.19E−06	8.50E−06	3.00E−07	6.00E−07	1.70E−06	2.54E−06	7.08E−07	1.45E−02
KMT2D	8.27E−08	2.03E−06	2.60E−06	2.10E−06	1.50E−06	5.00E−07	2.52E−06	7.48E−07	1.53E−02
ANK3	5.54E−10	9.92E−07	1.00E−06	4.73E−05	3.32E−04	3.12E−03	3.87E−07	8.72E−07	1.78E−02
DDN	1.79E−07	4.10E−06	4.70E−06	4.70E−06	1.60E−06	9.00E−07	4.94E−06	1.16E−06	2.36E−02
PRKAG1	8.27 E−08	2.74E−06	3.10E−06	1.90E−06	2.00E−06	1.00E−06	3.16E−06	1.64E−06	3.32E−02
ITIH3	1.99E−07	1.78E−05	2.17E−05	1.39E−05	8.00E−06	1.30E−06	1.49E−05	2.32E−06	4.66E−02