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. Author manuscript; available in PMC: 2017 Nov 8.
Published in final edited form as: ACS Chem Biol. 2017 Aug 29;12(9):2436–2447. doi: 10.1021/acschembio.7b00527

Figure 1. Summary of the high-throughput screen and hit identification.

Figure 1

Network Graph showing the chemical structures of 5,287 hits selected based on the hit criteria from the preliminary screen. Similar structures cluster together in the branches of the network based on their molecular topology. Structure of the three hits [SJ000291942 (1), SJ000063181 (2), and SJ00037178 (3)] grouped in cluster 5 and are highlighted in blue boxes.