Table 3.
Transcription factors with difference between the 5% O2 and 20% O2 groups separated by functional pathways.
| Function | Transcription factors |
|---|---|
| DNA-dependent transcription factors (processes that regulate frequency, rate, and extent of DNA transcription) | ATF4 CDX2 DDIT3 KEAP1 HSF1 |
| OTX2 PAF1 POU5F1 | |
| REST SREBF1 XBP1 | |
| HAND1 NANOG NFKB2 SOD2 SOX2 | |
|
| |
| Positive regulation of gene expression | ATF4 DDIT3 KEAP1 SREBF1 |
|
| |
| Negative regulation of gene expression | REST |
| HAND1 NANOG SOX2 | |
|
| |
| DNA-dependent transcription factors with specific binding | DDIT3 ATF4 HSF1 |
| POU5F1 OTX2 | |
| NANOG NFKB2 SOX2 | |
|
| |
| RNA metabolic process regulators (processes that regulate frequency, rate, and extent of chemical reactions involving RNA | ATF4 DDIT3 CDX2 HSF1 |
| POU5F1 OTX2 XBP1 | |
| HAND1 NANOG NFKB2 SOD2 SOX2 | |
Genes in italic upregulated in the 5% O2 group in comparison to the 20% O2 group. Genes in bold downregulated in the 5% O2 group in comparison to the 20% O2 group.