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. 2017 Oct 25;2017:4082102. doi: 10.1155/2017/4082102

Figure 8.

Figure 8

The role of SRT1720 and p53 in the downregulation of β-catenin induced by LPS in HUVECs. (a) Time-dependent changes in expression of β-catenin induced by 500 ng/mL LPS. (b) Pretreatment of SRT1720 prevented LPS-induced β-catenin downregulation. (c) Pretreatment of ex527 aggravated LPS-induced β-catenin downregulation. (d) SRT1720 attenuated LPS-evoked p53 319 acetylation. (e) p53 inhibition with PFT-α prevented LPS-induced EC hyperpermeability. (f) p53 inhibition with PFT-α prevented the LPS-induced decrease in β-catenin expression. n = 3∗P < 0.05 versus control, #P < 0.05 versus LPS.