Heroin-involved overdose deaths and heroin-related emergency department (ED) visits, by quarter, based on data from New York City Department of Health and Mental Hygiene, Bureau of Alcohol, Drug Use Prevention, Care, and Treatment; New York City Office of the Chief Medical Examiner; and New York City Department of Health and Mental Hygiene, Bureau of Vital Statistics; New York City, 2012-2015. Using Pearson correlation coefficient (r = .88, P < .001, based on t test, null hypothesis: r = 0). Analysis of data performed by Bureau of Alcohol, Drug Use Prevention, Care, and Treatment. Heroin-related ED visit risk ratios calculated by dividing observed visits by expected visits, with the latter value based on the mean number of visits determined using archived syndromic surveillance dataset from the New York City Department of Health and Mental Hygiene, Bureau of Communicable Diseases, consisting of information from 97% of the ED visits made to New York City hospitals during 2012. Abbreviation: Q, quarter.