Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 23;8(11):823–833. doi: 10.1007/s13238-017-0479-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Human ASPM mutant organoids show disrupted cerebral development. (A) Representative BF images of control and ASPM-2 organoids at different stages. (B) The diameter of organoids generated from each hiPSC lines. (C) Immunostaining of NE markers in control and ASPM-2 organoids. (D) The percentage of Ki67⁺ and pH3⁺ cells in VZ of the developing organoids. n = 3, 3 slices for control and ASPM-2 group. (E) Immunostaining for progenitor markers of control and ASPM-2 organoids on day 65. (F) Immunostaining of telencephalic, neuronal and progenitor marker of control and ASPM-2 organoids on day 65. (G–I) Immunostaining results for progenitor and pyramidal markers of control and ASPM-2 organoids on day 65. All data are presented as means ± s.e.m. *P < 0.05; ***P < 0.001; ****P < 0.0001. Scale bar: 200 μm in (A), 50 μm in (C, E–I)