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. 2017 Nov 7;7:14664. doi: 10.1038/s41598-017-15288-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Percentage of T-cell subpopulations in VL spleen of mice. (A) In comparison between the uninfected groups and between the infected groups of both the diets, the CD4+ population was significantly increased and the CD8+ population was significantly decreased in the diet-D. Whereas, in the comparison between the infected diet-D and its leptin-treated group, the CD8+ population was significantly increased and the CD4+ population was significantly decreased. (B) RT-qPCR analysis of exhaustive T-cell markers, Grz-A, and GM-CSF relative expression. In comparison between the infected groups of both the diets, the exhaustive T-cell markers (CTLA-4 and PD-1) and GM-CSF were significantly upregulated, and Grz-A was found to be unaltered in the diet-D. Whereas, in the comparison between the infected diet-D and its leptin-treated group, both the exhaustive markers and GM-CSF were significantly downregulated, and Grz-A was significantly upregulated in the leptin-treated group. Collective data of two independent experiments are shown.