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. 2017 Nov 7;7:14747. doi: 10.1038/s41598-017-15011-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circulating SOD2 and miRNAs plasma levels of REVE-2 patients. REVE-2 was a multicenter study that enrolled 246 patients with anterior wall Q-wave MI followed for one year with serial echographic studies at hospital discharge (day 3 to day 7) then 3 months and 1 year after MI and serial blood sampling at hospital discharge then 1 month, 3 months, and 1 year after MI. REVE-2 patients (n = 224) were divided as no remodelers (LVR <20%, n = 138)) (white) and high remodelers (LVR > 20%, n = 86) (grey), according to the LV remodeling determined as ((EDV1year − EDVbaseline)/EDVbaseline). (A) Quantification by ELISA of SOD2 in plasma from no LV remodeling (white, n = 138) and high LV remodeling (grey, n = 86) patients after 3 months and 1 year post-MI for all the population (left panel). Analysis were also performed by separating women (n = 46, 24 no LVR and 20 high LVR) and men (n = 200, 114 with no LVR and 66 with LVR) (right panel). Data are expressed as log (SOD2) and are represented in box plot with the central rectangle for the interquartile range, the segment inside the rectangle for the median and the segment outside for the minimum and maximum. (B) Visualization of the REVE-2 molecular network model¹⁷ at baseline centralized on direct miR-222-3p interaction. Detailed information are provided as Fig. 2 and Supplementary Table 3. (C) Quantification by RT-qPCR of miR-222-3p in plasma extracted from REVE-2 patients at baseline and after 3 months and 1 year post-MI for all the population (left panel). Analysis were also performed by separating women (n = 46, 24 no LVR and 20 high LVR) and men (n = 200, 114 with no LVR and 66 with LVR) (right panel). Data are expressed as log (miR/cel39) and are represented in box plot with the central rectangle for the interquartile range, the segment inside the rectangle for the median and the segment outside for the minimum and maximum. *p < 0.05; **p < 0.01 compared to no LV remodeling patients. (D) Pearson correlations between SOD2 and miR-222-3p in REVE-2 patients. The scatter plots show the correlation between SOD2 and miR-222-3p plasma levels at 3 month post-MI for all REVE-2 population (n = 246) (left panel), for men (n = 200) (middle panel) and women (n = 46)(right panel).