Figure 4.

The phagocytic capacity of monocytes from patients with PCD is similar to that of monocytes from healthy controls. The phagocytic capacity of monocytes from PCD patients (PCD), age-matched healthy pediatric controls (Ped CO) and healthy adult controls (Ad CO) was assessed by using Staphylococcus aureus labeled beads. The fluorescence intensity of these beads increases when taken up in the acid phagolysosomes of phagocytes. The fluorescence signal of the beads was measured by flow cytometry. The uptake of S. aureus labeled beads by monocytes from healthy children and PCD patients was expressed relative to the uptake by monocytes of the reference Ad CO (%). No significant difference in phagocytosis was detected between the monocytes of the PCD patients and the healthy controls (Mann Whitney U-test).