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. 2017 Nov 7;7:14634. doi: 10.1038/s41598-017-12660-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification and experimental validation of circulating/secretory miRNAs in SS-patient serum. (A) Schematic representation of the approach used for the detection of circulating/secretory miRNAs in SS-patients. (B) Heatmap and the hierarchical clustering of miRNA microarray analysis using patient serum in preoperative state as well as in cell culture media of SS cells. (C) Serum levels of the candidate markers in SS patients, age-matched benign tumour patients, and healthy individuals. *p < 0.05; Student’s t test. (D) Expression levels of candidate miRNAs in SS cells and human mesenchymal stem cells (hMSCs). Data are presented as mean ± S.D. (n = 3 in each group) *p < 0.05; Student’s t test. (E) Expression levels of candidate miRNA biomarkers in culture media of SS cells (SYO-1, YaFuSS, and HS-SY-II) and hMSCs. Data are presented as mean ± S.D. (n = 3 in each group) *p < 0.05; Student’s t test. (F) The expression dynamics of miR-92b-3p and miR-150-3p in the culture media of SS cell lines according to cell number and the culture duration. Data are presented as mean ± S.D. (n = 3 in each group) *p < 0.05; Student’s t test.