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. 2017 Nov 7;7:14634. doi: 10.1038/s41598-017-12660-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum expression levels of candidate miRNAs during tumour development in SS-bearing mice. (A) Scheme of the animal experiment. (B) The tumour volume plotted each week after tumour inoculation (left). The macroscopic appearance of SYO-1 tumours in each group of mice 1, 3 and 5 weeks after tumour injection are shown (right). (C) Serum miR-92b-3p and miR-150-3p expression at 0, 3, 4, and 5 weeks after tumour inoculation. *p < 0.05; Student’s t test (D) Pearson’s correlation between miR-92b-3p and miR-150-3p levels and tumour volume (R = 0.776 for miR-92b-3p, R = 0.486 for miR-150-3p, p < 0.05, respectively). (E) Relative serum miR-92b-3p and miR-150-3p levels at pre- and postoperative stages (n = 6 in each group) *p < 0.05; Student’s t test.