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. 2017 Nov 7;7:14634. doi: 10.1038/s41598-017-12660-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum miR-92b-3p expression levels and dynamics in synovial sarcoma patients in the validation cohort. (A) Serum miR-92b-3p expression levels in SS patients and control individuals in the validation cohort (p < 0.05) *p < 0.05; one-way ANOVA with Holm-Sidak’s multiple comparison test. (B) Receiver operating characteristic (ROC) curve analysis. ROC curve analysis indicated the AUC of 0.77 (95% confidence interval = 0.61–0.94) discriminating SS from age-matched benign tumour patients and healthy individuals. (C–F) Tumour monitoring of serum miR-92b-3p levels during multimodal therapies. Four SS patients including an 11 year old male with lower back involvement (C), 39 year old female (groin region) (D), 61 year old female (proximal thigh) (E), and 21 year old male (knee joint) (F) could be evaluated during the treatment. Abbreviations: WBC = white blood cell; Hb = hemoglobin; OP = operative surgery; Cx = chemotherapy; Rec = recurrence; Mets = metastasis; SD = stable disease; PD = progressive disease.