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. 2017 Nov 7;7:14634. doi: 10.1038/s41598-017-12660-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential diagnosis of synovial sarcoma from other soft tissue sarcomas by circulating/secreted miR-92b-3p. (A,B) The expression of miR-92b-3p and miR-150-3p in cells (A) and cell culture media (B) of SS (SYO-1, YaFuSS, HS-SY-II, and Yamato-SS) and the other STS cell lines (HT1080, NMS2, and UPS2023). The Mann-Whitney U test was used for comparison between groups. (C) Serum miR-92b-3p levels in SS patients and other STS patients (p < 0.001). The Mann-Whitney U test was used for comparison between groups. (D) ROC curve analysis of miR-92b-3p discriminating SS patients from other STS patients. AUC was 0.88 (95% confidence interval = 0.72–1.0). (E) Serum miR-150-3p expression levels in SS patients and other STS patients. The Mann-Whitney U test was used for comparison between groups. (F) ROC curve analysis of miR-150-3p discriminating SS patients from other STS patients. AUC was 0.54 (95% confidence interval = 0.33–0.75).