Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 7;7:14761. doi: 10.1038/s41598-017-15348-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The inhibitory effect of 5-HT on the LPS-induced pro-inflammatory cytokine production of human macrophages is dependent on 5-HT7R and PKA. (A) Production of LPS-stimulated IL-12p40 and TNFα by M-MØ non-treated (-) or pretreated with 5-HT (6 h) in the presence or absence of the 5-HT7R antagonists SB269970 or SB258719 (n = 6; *p < 0.05; **p < 0.01; ***p < 0.001). (B) Production of LPS-stimulated IL-12p40 and TNFα by M-MØ non-treated (-) or pretreated (6 h) with either 5-HT (5HT) or the 5-HT7R agonist AS19 (n = 6; *p < 0.05; **p < 0.01). (C) Production of LPS-stimulated IL-12p40 and TNFα by M-MØ non-treated (-) or pretreated with 5-HT (5HT, 6 h) in the presence or absence of the PKA inhibitor RP8 (n = 6; *p < 0.05; **p < 0.01).