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. 2017 Nov 7;7:14623. doi: 10.1038/s41598-017-15191-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mertk ^−/− mice have reduced retinyl ester accumulation. (A) Schematic of the visual (retinoid) cycle that occurs in RPE (pink) and POS (gray). (B) P20-P21 mice were dark adapted overnight and HPLC analysis was performed to quantify all-trans-retinyl esters and (C) 11-cis-retinal. Individual points within bars are the average value for both eyes from one mouse: Mertk ^+/+(n = 5) Mertk ^+/+ Bai1 ^Tg (n = 4) Mertk ^−/− (n = 5) Mertk ^−/− Bai1 ^Tg (n = 5). Error bars represent SEM. Statistical analysis was performed by one-way ANOVA. Multiple comparisons were corrected with a post-hoc Tukey’s test. **p < 0.01.